Table 3.
TERT- positivity: diagnostic accuracy, sensitivity, specificity, and positive predictive value for melanoma among 86 melanomas and 72 nevi
| TERT-positivity* | Diagnostic Accuracy % (95% CI) |
Sensitivity Analysis | Specificity Analysis | PPV % (95% CI) |
NPV % (95% CI) |
||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| Sensitivity % (95% CI) |
Number | Specificity % (95% CI) |
Number | ||||||
|
|
|
||||||||
| True Positive | False Negative | True Negative | False Positive | ||||||
|
|
|
||||||||
| Positives have a hotspot mutation | 87.3 (81.1–92.1) | 77.9 (68.9–85.4) | 67 | 19 | 98.6 (95.8–100) | 71 | 1 | 98.5 (95.6–100) | 78.9 (72.6–85.4) |
Abbreviations: CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.
*
Defined as harboring a hotspot TERT promoter mutation: -124C>T, -124_125CC>TT, -138_139CC>TT or -146C>T.