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. Author manuscript; available in PMC: 2019 Apr 5.
Published in final edited form as: Leukemia. 2018 Sep 11;33(4):918–930. doi: 10.1038/s41375-018-0254-2

Figure 1: AML negatively impacts the endosteal niche.

Figure 1:

(a) MSC and OPC harvest workflow. Long bones from control and xenografted mice are removed, flushed, crushed, and incubated in Collagenase II. Disadhered cells are then filtered, stained with antibodies, and sorted via FACS. (b) CFU-F assay of MSCs and OPCs derived control and AML xenografted animals. Error bars are standard error of the mean (n= 8, 13, 8, 8 animals per condition). (c) The ratio of MSCs / OPCs in control and AML xenograft animals. Error bars are standard error of the mean (n= 22, 14, 4, 6 animals per condition). Significance in (b) and (c) was determined using ANOVA and Bonferroni correction. *P<0.05, ***P<0.001.