Fig. 3.

Uterine serous adenocarcinoma with HER2 amplification. A representative histology image of patient's hysterectomy specimen showing classic features of high-grade serous carcinoma with well-formed papillae lined by pleomorphic tumor cells with prominent nucleoli (A). Whole-exome sequencing analysis revealed HER2 amplification as illustrated in the copy number alteration plots (C and D) of chromosome 17 and HER2 gene, respectively. Validation assays included immunohistochemistry (B) and fluorescence in situ hybridization (E).