Fig. 6.

Cumulative distribution functions of the p-values from the LH morphometric comparisons of NC vs. e4-carriers, NC vs. HM, NC vs. HT and HT vs. HM, plotted against the expected p-values under the null hypothesis of no group differences among the comparisons. In false discovery rate methods, any cumulative distribution plot that rises steeply is a sign of a significant signal being detected, with curves that rise faster denoting higher effect sizes. The steep rise of the cumulative plot relative to p-values that would be expected by chance can be used to compare the detection sensitivity of different statistics derived from the same data. The deviations of the statistics from the null distribution generally increased from NC vs. HT to NC vs. HM in the cognitively unimpaired individuals study, suggesting that the APOE-e4 allele dose may be associated with faster atrophy of the LH. LH: left hippocampus; NC: no-carriers; HT: heterozygotes; HM: homozygotes.