Table 1.
Parameters of Membrane Property and Action Potential
| Control |
High K+ (1.5K) |
|||
|---|---|---|---|---|
| High CF (n = 18) | Low CF (n = 17) | High CF (n = 7) | Low CF (n = 10) | |
| Membrane property | ||||
| Rm (MΩ) | 62.2 ± 4.5 | 61.8 ± 4.7 | 19.0 ± 1.6a,b | 35.0 ± 2.9a |
| Vm (mV) | −59.2 ± 1.3 | −58.5 ± 1.0 | −65.9 ± 2.2b,c | −56.0 ± 1.0 |
| Cm (pF) | 40.3 ± 1.8 | 45.6 ± 2.2 | 43.9 ± 3.9 | 48.6 ± 3.9 |
| τm (ms) | 2.4 ± 0.1 | 2.8 ± 0.2 | 0.8 ± 0.1a,b | 1.7 ± 0.2a |
| No. of spike (1-nA input) | 2.0 ± 0.2d | 3.2 ± 0.5 | 1.0 ± 0.1a,b | 1.6 ± 0.4 |
| Action potential | ||||
| Th. current (nA) | 0.3 ± 0.1 | 0.2 ± 0.1 | 1.5 ± 0.2a,b | 0.3 ± 0.1 |
| Th. potential (mV) | −42.3 ± 1.4 | −45.3 ± 0.9 | −44.7 ± 3.2 | −41.7 ± 1.3c |
| Amplitude (mV) | 44.3 ± 1.4 | 47.2 ± 2.3 | 22.8 ± 1.9a,b | 49.2 ± 1.5 |
| Half-width (ms) | 0.5 ± 0.1d | 0.4 ± 0.1 | 0.3 ± 0.1a,b | 0.5 ± 0.1 |
| Max. dV/dt (V/s) | 224.2 ± 12.9 | 255.5 ± 16.8 | 148.5 ± 9.1a,b | 242.9 ± 13.7 |
| Mini. dV/dt (V/s) | −105.5 ± 7.6d | −127.8 ± 7.6 | −127.9 ± 6.8 | −129.2 ± 7.9 |
| Latency (ms) | 2.3 ± 0.1 | 2.3 ± 0.1 | 1.1 ± 0.1a,b | 2.1 ± 0.1 |
Input resistance (Rm), resting potential (Vm), membrane capacitance (Cm), and membrane time constant (τm).
a
p < 0.01 (between control and high-K+ condition).
b
p < 0.01 (between high- and low-CF neurons).
c
p < 0.05 (between control and high-K+ condition).
d
p < 0.05 (between high- and low-CF neurons).