Table 3.

Effects of High-K⁺ Treatment on Membrane Potential

	Control	1.5K	2K	3K
High CF
Onset	−53.2 ± 0.4 (n = 6)	−46.1 ± 0.7 (n = 7)	−40.4 ± 1.2 (n = 6)	−36.1 ± 1.3 (n = 6)
End	−55.6 ± 0.7 (n = 6)a	−52.7 ± 0.3 (n = 6)b	−45.3 ± 1.5 (n = 6)a	−39.0 ± 0.9 (n = 7)
Low CF
Onset	−52.4 ± 0.7 (n = 9)	−45.6 ± 0.6 (n = 10)	−40.8 ± 0.6 (n = 7)	−35.5 ± 0.8 (n = 5)
End	−56.0 ± 1.7 (n = 5)	−47.1 ± 1.1 (n = 9)c	−43.1 ± 1.0 (n = 9)	−37.4 ± 0.4 (n = 8)a

Membrane potential was measured at onset (11DIV) and end (14DIV) of 3-day treatment in the corresponding culture medium.

[K⁺] was 5.3 mM, 7.95, 10.6, and 15.9 mM for control, 1.5K, 2K, and 3K medium, respectively.

High- K⁺ treatment depolarized the membrane (p < 0.01, compared with control), and the level of depolarization depended on [K⁺].

^ap < 0.05 (between onset and end of high- K⁺ treatment).

^bp < 0.01 (between onset and end of high- K⁺ treatment).

^cp < 0.01 (between high- and low-CF neurons).