Table 2.
Connections identified using ptau × ∆Time as a predictor for longitudinal changes in WaCSMD (multiple comparisons corrected using Bonferroni at 0.05) sorted by corresponding p-values (column 1–3), and the correlation between simple MD changes and ptau × ∆Time on the identified connections (column 4). Two ROIs (i.e., ROI 1 and ROI 2) represent one connection and the ROI indices corresponds to their labels in the IIT template.
| ROI 1 (IIT index) | ROI 2 (IIT index) | p-Value (1e-4) (WaCSMD) | Correlation (simple MD) |
|---|---|---|---|
| ctx_rh_G_and_S_frontomargin (12101) | ctx_rh_S_intrapariet_and_P_tran (12157) | 0.0014 | 0.3157 |
| ctx_rh_G_and_S_frontomargin (12101) | ctx_lh_G_and_S_transv_frontopol (11105) | 0.0046 | 0.0711 |
| Right-Hippocampus (53) | ctx_rh_G_and_S_frontomargin (12101) | 0.0147 | 0.3671 |
| ctx_rh_G_and_S_frontomargin (12101) | ctx_rh_G_front_middle (12115) | 0.0225 | 0.2554 |
| Right-Amygdala (54) | ctx_rh_G_cingulum-Post-ventral (12110) | 0.0274 | 0.3026 |
| Left-Caudate (11) | Right-Amygdala (54) | 0.0776 | 0.3071 |
| ctx_rh_G_and_S_frontomargin (12101) | ctx_rh_S_precentral-sup-part (12170) | 0.0859 | 0.2507 |
| Right-Caudate (50) | ctx_rh_G_and_S_frontomargin (12101) | 0.1022 | 0.4041 |
| Right-Hippocampus (53) | Left-Amygdala (18) | 0.1270 | 0.3483 |
| Left-Caudate (11) | Right-Hippocampus (53) | 0.1611 | 0.2017 |
ctx: cortex, lh: left hemisphere, rh: right hemisphere, S: sulcus, G: gyrus, sup: superior, inf: inferior, post: posterior, frontomargin: frontomarginal, pariet: parietal, tran/transv: transverse, frontopol: frontopolar.