Table 3.

Results of the association of ESR1 polymorphisms with radiographic knee OA risk.

Subgroup	Genetic Model	Type of Model	Heterogeneity		Odds Ratio				Publication Bias
			I2 (%)	PH	OR	95% CI	Ztest	POR	PBeggs	PEggers
rs2234693 (n=14)	C vs. T	Random	77.97	≤0.001	1.067	0.921–1.236	0.866	0.386	0.912	0.521
	CC vs. TT	Random	69.44	≤0.001	1.158	0.892–1.504	1.100	0.271	0.912	0.638
	CT vs. TT	Fixed	26.70	0.168	1.164	1.053–1.286	2.961	0.003	0.100	0.060
	CC + CT vs. TT	Random	56.64	0.005	1.113	0.945–1.310	1.279	0.201	0.324	0.105
	CC vs. CT + TT	Random	73.70	≤0.001	1.110	0.876–1.406	0.861	0.389	0.661	0.683
Ethnicity
Asian (n=9)	C vs. T	Random	80.53	≤0.001	1.126	0.881–1.439	0.951	0.342	0.602	0.306
	CC vs. TT	Random	74.38	≤0.001	1.282	0.821–2.000	1.093	0.274	0.916	0.424
	CT vs. TT	Random	51.84	0.034	1.050	0.821–1.343	0.386	0.699	0.916	0.056
	CC + CT vs. TT	Random	69.93	0.001	1.095	0.818–1.466	0.611	0.541	0.916	0.163
	CC vs. CT + TT	Random	70.98	0.001	1.307	0.901–1.895	1.409	0.916	0.916	0.632
Caucasian (n=4)	C vs. T	Random	65.99	0.032	0.997	0.860–1.156	−0.039	0.969	0.308	0.204
	CC vs. TT	Fixed	52.37	0.098	1.081	0.911–1.283	0.888	0.374	0.308	0.190
	CT vs. TT	Fixed	0.00	0.913	1.150	0.993–1.330	1.868	0.062	0.734	0.680
	CC + CT vs. TT	Fixed	0.00	0.739	1.139	0.992–1.307	1.841	0.066	0.308	0.338
	CC vs. CT + TT	Random	73.23	0.011	0.906	0.693–1.185	−0.720	0.472	0.308	0.192
rs9340799 (n=11)
Asian (n=9)	G vs. A	Random	87.08	≤0.001	0.915	0.705–1.187	−0.671	0.502	0.096	0.002
	GG vs. AA	Random	76.01	≤0.001	0.792	0.497–1.260	−0.985	0.325	0.061	0.007
	GA vs. AA	Random	66.35	0.001	0.942	0.749–1.185	−0.512	0.609	0.008	≤0.001
	GG + GA vs. AA	Random	77.09	≤0.001	0.882	0.680–1.143	−0.949	0.343	0.005	≤0.001
	GG vs. GA + AA	Random	58.36	0.008	0.944	0.928–1.195	−0.437	0.662	0.042	0.018
	G vs. A	Random	88.28	≤0.001	0.870	0.619–1.223	−0.802	0.423	0.173	0.005
	GG vs. AA	Random	74.84	≤0.001	0.722	0.416–1.255	−1.155	0.248	0.251	0.052
	GA vs. AA	Random	56.20	0.019	0.885	0.686–1.141	−0.944	0.345	0.028	0.003
	GG + GA vs. AA	Random	72.05	≤0.001	0.817	0.607–1.101	−1.326	0.185	0.028	0.003
	GG vs. GA + AA	Random	58.07	0.014	0.877	0.590–1.302	−0.653	0.514	0.175	0.097