Fig. 2.

Correlations between paracellular permeability and brain function in healthy controls and women with IBS. A. Significant whole-brain correlations between levels of ⁵¹Cr-EDTA passage (paracellular permeability) and resting state brain function in the DMN for the HCs. B. Significant whole-brain correlations between levels of ⁵¹Cr-EDTA passage and resting state brain function in the DMN for the IBS patients. All statistical maps are thresholded at p < 0.05, Family Wise Error corrected for comparing across the whole brain and masked with the significant group-difference results shown in Fig. 1A. Color bars are scaled in terms of -log₁₀(p). For the statistical maps shown, warm colors indicate brain regions with increased resting state functional connectivity with increased paracellular passage of ⁵¹Cr-EDTA; cool colors indicate regions with increased functional connectivity with decreased paracellular passage of ⁵¹Cr-EDTA.