Fig. 3.

Correlations between paracellular permeability and white matter microstructural integrity. A. Significant between-group differences in the correlation of paracellular permeability and fractional anisotropy (FA). B. Significant whole-brain correlations between levels of ⁵¹Cr-EDTA passage and WM microstructure as quantified by FA for the HCs. C. Significant whole-brain correlations between levels of ⁵¹Cr-EDTA passage and WM microstructure as quantified by FA for the IBS patients. All statistical maps are thresholded at p < 0.05, Family Wise Error corrected for comparing across the whole brain. Color bars are scaled in terms of –log₁₀(p). For the statistical maps shown in A, warm colors indicate WM tracts with significant positive between-group differences for the (IBS-HCs) contrast; cool colors indicate WM tracts with significant negative between-group differences for the (IBS-HCs) contrast. For the statistical maps shown in B–C, results are masked with significant group-differences shown in A. Warm colors indicate WM tracts with increased FA with increased paracellular passage of ⁵¹Cr-EDTA; cool colors indicate tracts with increased FA with decreased paracellular passage of ⁵¹Cr-EDTA.