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. 2018 Dec 31;6(1):16–24. doi: 10.1016/j.gendis.2018.12.003

Figure 3.

Figure 3

Canonical pathway for α2β1 signaling. Upon collagen or laminin binding to integrin α2β1, a series of signaling events occur to promote survival, proliferation, migration, and invasion. Integrins are often recycled to provide a refreshed pool of integrins to the surface membrane.