. 2018 Dec 31;6(1):16–24. doi: 10.1016/j.gendis.2018.12.003

Table 2.

ITGA2 gene polymorphisms associated with multiple types of cancer.

Type of Cancer	ITGA2 status/role
Breast Cancer	ITGA2 1648G > A (95% of the breast cancer patients expressed the 1648AA genotype).⁹
Colorectal cancer	ITGA2 807C > T polymorphism was associated with reduced colorectal cancer risk but no effects on overall survival or relapse-free survival.10, 11
Gastric Cancer	ITGA2 807C > T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.¹²
Lymph node positive breast cancer	No correlation of polymorphism with disease-free survival or relapse-free survival.¹³
Melanoma	Very conserved polymorphisms have small effects in melanoma.⁸⁴
Colon cancer	Up-regulated.⁸⁵