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. 2019 Mar 5;10:361. doi: 10.3389/fimmu.2019.00361

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Copyright © 2019 Pararasa, Zhang, Tull, Chong, Siu, Guesdon, Chavele, Sanderson, Langmead, Kok, Spencer and Vossenkamper.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequency of blood CD27⁻IgD⁻ subsets and β7 integrin expression in CD and UC patients stratified according to CRP levels and remission status. Three subsets of CD27⁻IgD⁻ B cells (CD27⁻IgA⁺, CD27⁻IgG⁺, and CD27⁻IgM⁺) are presented as percentage of CD19 positive cells in (A) and in (B) the percentage of individual populations expressing of β7 integrin. For (A,B), UC < 5 n = 13, UC > 5 n = 4, CD < 5 n = 19, CD > 5 n = 16; for (C,D) HC n = 22, UC active n = 6, UC remission n = 11, CD active n = 9 and CD remission n = 22. Data is analyzed by Mann-Whitney U test (black bars and asterisks) or Kruskal-Wallis ANOVA test (red bars and asterisks) where p < 0.05 = ^*, p < 0.01 = ^**, p < 0.001 = ^*** and p < 0.0001 = ^****.