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. 2018 Dec 4;21:101621. doi: 10.1016/j.nicl.2018.101621

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Statistic maps of interaction effects of APOE with MS4A (rs670139) on functional connectivity (FC) in executive control network (ECN) after adding grey matter maps as covariance of no interest. Genetic interaction affects FC between the dorsal lateral prefrontal cortical (DLPFC) seed and the left supramarginal gyrus and FC between the orbital frontoinsular (OFI) seed and the left middle frontal gyrus (upper row), and partial regression plots show correlation between calculation score and FC (lower row). Residuals are plotted for each variable to adjust for the effect of education (years). The 95% confidence interval is the area enclosed by the dashed curves. GG-carriers: MS4A-rs670139-GG carriers; T-allele-carriers: MS4A-rs670139-T-allele carriers.