Fig. 3.

Differences between normal controls (NC) and ALS patients in global network parameters as a function of network density. The 95% confidence interval and group differences in (A) normalized path length, (B) normalized clustering coefficient, (C) small-world index, (D) global efficiency, (E) local efficiency and (F) modularity. The * marker denotes the difference between NC and ALS patients; the * signs lying outside of the confidence intervals indicate the density where the difference is significant at P < .05. The positive values indicate ALS patients > NC and negative values indicate ALS patients < NC.