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. 2019 Mar 5;10:384. doi: 10.3389/fimmu.2019.00384

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Copyright © 2019 Kwon, Lee, Lee, Youn, Kim, Hong, Lee, Yoo, Robinson and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between anti-PFDN5 antibody and AS with uveitis. (A) Protein microarray analysis of autoreactivity to PFDN5 in sera from patients with various autoimmune diseases in the Multiple Autoimmune Disease Genetics Consortium Cohort. (B) Receiver operating characteristic curve for anti-PFDN5 as a biomarker of uveitis in AS. (C) ELISA analysis of anti-PFDN5 antibody levels in sera from Korean cohort. (D) ELISA analysis of PFDN5 protein levels in sera from Korean cohort. Data presented as mean ± SEM. ^*p < 0.05; ^**p < 0.01, by Mann–Whitney U-test. PFDN5, prefoldin subunit 5; RA, rheumatoid arthritis; CCP, cyclic citrullinated protein; JIA, juvenile idiopathic arthritis; PsA, psoriatic arthritis; PAH, pulmonary artery hypertension; AUC, area under the curve; HC, healthy control; ELISA, enzyme-linked immunosorbent assay; ns, not significant.