Table 1.

Observed heat capacity effects resulting from binding DBDs to the minor and major grooves of DNA separated into contributions from the dehydration of protein and DNA

ΔCp values in J K⁻¹ mol⁻¹. Values of predicted ΔCp^DNA were calculated using the magnitudes of ΔASA^polar and ΔASA^apolar in the penultimate column and the corresponding equations for the minor and major groove binders given in Fig. 2 and Table 2 (below)

Thermodynamic data obtained for: Lef79, SRY, Sox5, HMG-D74 (Dragan et al. 2004); Core DBD2 (Dragan et al. 2003); desAntp and desNK2 (Dragan et al. 2006); TFIIIA (Liggins and Privalov 2000); FOXP2 (Morris et al. 2018); Cro (Takeda et al. 1992); Mat α2 (Carra and Privalov 1997). Sox5/DNA complex structure—unpublished data from (Read et al. 2018)