Fig. 1.

Pedigrees of the families described in this study. Above each pedigree, the C1R genotype in the affected individuals is specified on nucleotide and predicted protein levels. The whole pedigree of family B has been published elsewhere; identification codes are identical with Kapferer-Seebacher et al. [1]. The arrows indicate the individuals who were available for neurological examination. All indicated individuals were investigated by MRI and had brain white matter abnormalities, except individual A:III-1 at age 7 years