Table 4:
Logistic regression analysis of variables associated with results of DNA PCR HIV testing at screening of HIV-exposed infants aged 4–12 weeks
| Unweighted MTCT frequency |
Weighted proportion (%) |
Odds ratio (95% CI) |
p value | Adjusted odds ratio (95% CI) |
p value | |
|---|---|---|---|---|---|---|
| Mother’s reported timing of ART initiation | ||||||
| During this pregnancy | 34/1081 | 3·4%(1·5–7·6) | 2·5(0·5–11·9) | 0·22 | 2·5(0·5–11·9) | 0·22 |
| Post partum | 4/33 | 19·1%(4·6–53·5) | 16·5(1·6–169·5) | 0·0224 | 16·7(1·6–171·5) | 0·0223 |
| Stopped ART | 2/17 | 10·2%(2·5–33·2) | 8·0(1·3–50·3) | 0·0305 | 8·5(1·6–45·4) | 0·0171 |
| Not on ART | ||||||
| HIV-positive status known during | 6/49 | 4·1%(1·3–12·5) | 3·0(0·6–13·8) | 0·15 | 3·0(0·7–13·5) | 0·13 |
| pregnancy | ||||||
| HIV-positive status unknown during | 24/132 | 21·1%(12·3–33·9) | 18·7(8·3–42·1) | <0·0001 | 19·1(8·5–43·0) | <0·0001 |
| pregnancy | ||||||
| Before this pregnancy | 18/1148 | 1·4%(0·4–4·4) | 1·00(ref) | ·· | 1·00(ref) | ·· |
| Regional strata | ||||||
| Blantyre | 20/551 | 3·3%(1·8–5·8) | 1·2(0·5–2·7) | 0·72 | 1·1(0·4–2·5) | 0·90 |
| South rural | 21/635 | 3·5% (1·5–7·7) | 1·2(0·4–3·5) | 0·67 | 1·4(0·5–3·5) | 0·47 |
| Lilongwe | 27/653 | 4·2%(3·3–5·3) | 1·5(0·8–2·9) | 0·21 | 1·4(0·7–2·8) | 0·27 |
| North-central rural | 20/621 | 2·8%(1·6–5·1) | 1·00(ref) | ·· | 1·00(ref) | ·· |
Analyses are based on 2460 mother–infant pairs; 18 had missing data for mother’s reported timing of ART initiation and 27 had missing data for known HIV-positive status during pregnancy. Mother’s reported timing of ART initiation and known HIV-positive status during pregnancy were combined into a single variable. Not on ART was split into known and unknown HIV-positive status during pregnancy. MTCT=mother-to-child transmission. ART=antiretroviral therapy.