Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 5;10:194. doi: 10.3389/fphys.2019.00194

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Nurminen, Seuter and Carlberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Classification of primary vitamin D target genes. The 160 primary vitamin D target genes that show H3K4me3 marks at their TSS regions can be segregated into four classes. The structure of the genes into TSS and enhancer regions is schematically depicted. Genes of classes 1 and 2 display VDR binding to their TSS regions, while for those of classes 3 and 4 no VDR binding can be detected. The 59 genes of class 1 and the 52 genes of class 3 have significant (p < 0.05) effects of 1,25(OH)₂D₃ on H3K4me3, H3K27ac, VDR, PU.1 and/or CEBPA binding strength on their enhancer region, while this is not observed for the 23 genes of class 2 and the 26 genes of class 4. In addition, for the respective classes the distribution of the genes of into the fold change (FC) groups A, B and C (Supplementary Figure S2) as well as the average FC is indicated.