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. 2019 Mar 5;10:172. doi: 10.3389/fphar.2019.00172

Figure 2.

Figure 2

Diagram of classic molecular mechanism of PARP14 as a drug target. PARP14 acts as the molecular switch that controls IL-4 dependent gene transcription. In the absence of IL-4, PARP14, with HDAC2 and HDAC3 complex, binds the gene promoter to silence the gene. Subsequently, with IL-4 occurrence, STAT6 is activated and binds the specific promoter, leading to the mono-ADP ribosylation of PARP14, HDAC2, and HDAC3. This facilitates the dissociation of PARP14 and HDACs complex from the promoter, activating transcription co-factors such as p300, NCoA-1 and NCoA-3 to bind to the promoter, effectively initiating gene transcription (Mehrotra et al., 2011).