Table 1.
PARP14 ligands and their crystal structures available in PDB.
| PDB ID | Ligand | Target domain | Structure |
|---|---|---|---|
| 3GOY | 3-aminobenzamide | Catalytic domain |  |
| 3SE2 | phenanthridin-6(5H)-one | Catalytic domain |  |
| 3SMI | 2-{[(3-amino-1H-1,2,4-triazol-5-yl)sulfanyl]methyl}-8-methylquinazolin-4(3H)-one | Catalytic domain |  |
| 3SMJ | 2-methyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one | Catalytic domain |  |
| 4F1L | (2Z)-4-[(3-carbamoylphenyl)amino]-4-oxobut-2-enoic acid | Catalytic domain |  |
| 4F1Q | (2E)-4-[(3-carbamoylphenyl)amino]-4-oxobut-2-enoic acid | Catalytic domain |  |
| 4PY4 | 2-({4-[(1R)-1-(dimethylamino)ethyl]phenyl}amino)-6-fluoro-1,3-benzothiazole-4-carboxamide | Catalytic domain |  |
| 5LXP | ~{N}′-(3-aminocarbonylphenyl)-~{N}-[[1-[(2~)-2-phenylpropyl]-1,2,3-triazol-4-yl]methyl]pentanediamide | Catalytic domain |  |
| 5LYH | 3-[2-[4-[2-[[4-[(3-aminocarbonylphenyl)amino]-4-oxidanylidene-butanoyl]amino]ethyl]-1,2,3-triazol-1-yl]ethylsulfamoyl]benzoic acid | Catalytic domain |  |
| 5NQE | 3-[[4-[4-(4-fluorophenyl)piperazin-1-yl]-4-oxidanylidene-butanoyl]amino]benzamide | Catalytic domain |  |
| 5V7T | N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-b]pyridazin-6-amine | Catalytic domain |  |
| 5V7W | 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | Catalytic domain |  |
| 6G0W | 4-[3-[4-(4-fluorophenyl)piperidin-1-yl]carbonylphenoxy]benzamide | Catalytic domain |  |
| 5O2D | ~-[2-(9~-carbazol-1-yl)phenyl]methanesulfonamide | Macro domain 2 |  |
| 3Q6Z | adenosine-5-diphosphoribose | Macro domain 1 |  |
| 3Q71 | adenosine-5-diphosphoribose | Macro domain 2 |  |
| 3VFQ | adenosine-5-diphosphoribose | Macro domain 1/2 |  |
| 4D86 | adenosine-5-diphosphate | Macro domain 1/2 |  |
| 4ABK | adenosine-5-diphosphoribose | Macro domain 3 |  |