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. 2019 Mar 5;7:57. doi: 10.3389/fped.2019.00057

Figure 1.

Figure 1

In vitro-based platforms to investigate human brain circuitry. Schematic illustrating different approaches to investigate human brain circuitry in vitro. Patient-specific somatic cells such as skin fibroblasts or peripheral blood mononuclear cells (PBMCs) that are easily isolated can be reprogrammed into hiPSCs using the Yamanka factors (OCT3/4, SOX2, c-MYC, and KLF4). hiPSCs can then be used as a source for generating multiple cell types in various platforms to investigate human brain circuitry.