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. 2019 Mar 5;10:394. doi: 10.3389/fmicb.2019.00394

FIGURE 4.

FIGURE 4

Overall structure of Plasmodium plasmepsins. (A) Cartoon representation of overall structure of Plasmepsin II (PDB: 1IF4). Flexible proline rich loop is depicted in yellow and catalytic aspartates Asp34 and Asp214 are shown as blue spheres. Residues defining the catalytic cavity Val78 (orange) and Leu292 (yellow) are shown as spheres. (B) Cartoon representation of overall structure of Plasmepsin V (PDB: 4ZL4). Free C140 (within the flap) and cysteine residues forming disulfide linkages are shown in yellow. Helix-turn-helix motif is unique to PlmV unlike all other plasmodial plasmepsins and aspartyl proteases. All structure figures have been made in Pymol.