Table 5.

Comparison of clinical & laboratory characteristics between cases with Ph as sole cytogenetic aberration & cases with ACAs in CML patients.

Clinical parameters	Karyotype	De novo CP		IM Resistant CP		Accelerated phase		Blast crisis
		Mean	P-value	Mean	P-value	Mean	P-value	Mean	P-value
Hb, gm%	Ph alone	11.02	0.761	10.39	0.738	9.71	0.331	8.70	0.017
	ACAs	10.90		10.11		9.14		10.00
WBC, × 109/L	Ph alone	268.79	0.389	327.83	0.150	153.82	0.511	114.68	0.665
	ACAs	258.51		162.00		170.31		257.39
PLC, × 109/L	Ph alone	364.51	0.346	261.70	0.448	335.75	0.988	200.24	0.126
	ACAs	405.33		236.56		378.98		152.04
BM Blast,%	Ph alone	4.56	0.202	2.51	0.150	12.58	0.141	48.92	0.144
	ACAs	4.35		4.11		14.21		59.61
PB Blast,%	Ph alone	4.30	0.675	1.80	0.182	12.38	0.165	48.27	0.936
	ACAs	4.13		2.78		13.71		48.74
LDH, IU/L	Ph alone	2457.36	0.630	2471.44	0.515	2593.55	0.799	3845.42	0.139
	ACAs	2648.00		2538.28		2725.56		2999.58

Hb, Hemoglobin; WBC, White Blood Cell Count; PLC, Platelet Count; BM, Bone Marrow; PB, Peripheral Blood; LDH, Lactate dehydrogenase; ACAs, Additional Chromosomal Aberrations; Ph, Philadelphia Chromosome. All statistical calculations were performed using SPSS software version 21. Student's t-test and Mann Whitney U-test was used to find the difference in the distribution of covariates such as Hb (gm%), TC (cmm), Platelet (cmm), LDH (IU/L), PB Blast (%), and BM blast (%) between cases with Ph as sole cytogenetic aberration and cases with ACAs. A P < 0.05 was taken as statistically significant.