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. 2019 Mar 11;10(3):238. doi: 10.1038/s41419-019-1485-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a IF staining indicated the expression levels of sweat-gland-specific markers (CK19, CK18, and αSMA), and functional markers (AQP5, αATP). b Gene expression of CK19, CK18, and AQP5 in sweat gland cells during the whole culture until to passage 2. The expression levels were normalized to that in epidermal cells (EPC). D0: pre-seed sweat gland cell; P0, P1, P2: the cells cultured in organoids at day 5 after passage 0, 1, and 2. c IF staining indicated the expression levels of epidermal cell markers, CK14, CK5, and CK10. d Gene expression of CK14, CK5, and CK10 in sweat gland cells. e Representative images of swear gland cells derived from organoids in monolayer culture. f IF staining of the epithelial cell adhesion molecule (EpCAM), and E-cadherin (E-Cad) in monolayer cultured swear gland cells. g Expression of epidermal cell markers, CK14, CK5 and CK10. h Expression of sweat gland stem cell markers, αSMA and SOX9. i Expression of sweat-gland-specific markers, CK18, CK19, and AQP5. Scale bars: 50 μm. SGC sweat gland cell, IF immunofluorescence