Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 11;10(3):236. doi: 10.1038/s41419-019-1487-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a MTT assay of HCT116 colon cancer cells expressing an empty vector (−) or a vector containing myc-tagged PRMT5 (+) in SCR (−) or NAA40-KD (+) conditions. Error bars represent the mean ± s.d of three biological replicates. Unpaired two-tailed Student’s t-test was used (**p < 0.01). Western blot analysis (right panel) was performed to detect ectopic expression of tagged PRMT5 using an antibody against myc. β-actin was used as a loading control. The values below the blot were determined by densitometry analysis. b Meta-analysis of PRMT5 expression levels extracted from the TCGA data portal in 647 colorectal cancer (CRC) and 51 normal patient samples. The Mann–Whitney test was used for the statistical analysis (***p < 0.001). c, d Scatter plots illustrating the correlation between the expression of NAA40 and PRMT5 (c) or between NAA40 and PRMT7 (d) in 647 CRC patient samples extracted from the TCGA database. The red line indicates the linear regression slope. Statistical analysis was performed using Pearson’s rank correlation coefficient (r)