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. 2019 Mar 11;9:4055. doi: 10.1038/s41598-019-40640-4

Table 1.

Ten newly identified compounds that displayed high Orco antagonist activity (greater than 80% inhibition at 3 mM) in Fig. 4D were further investigated by concentration-inhibition analysis.

Compound IC50 (μM) Estimated Vapor Pressure (mmHg at 25 °C) Boiling Point (degrees C)
graphic file with name 41598_2019_40640_IEq1_HTML.gif 47 ± 3 0.008 261.4
graphic file with name 41598_2019_40640_IEq2_HTML.gif 48 ± 5 0.03 247.7
graphic file with name 41598_2019_40640_IEq3_HTML.gif 135 ± 15 0.09 218.3
graphic file with name 41598_2019_40640_IEq4_HTML.gif 195 ± 18 0.04 244.7
graphic file with name 41598_2019_40640_IEq5_HTML.gif 251 ± 39 0.2 211.7
graphic file with name 41598_2019_40640_IEq6_HTML.gif 262 ± 24 0.04 209.2
graphic file with name 41598_2019_40640_IEq7_HTML.gif 262 ± 29 0.01 264.3
graphic file with name 41598_2019_40640_IEq8_HTML.gif 527 ± 84 0.29 201.5
graphic file with name 41598_2019_40640_IEq9_HTML.gif 554 ± 51 0.13 220.9
graphic file with name 41598_2019_40640_IEq10_HTML.gif 719 ± 48 0.08 204.1

IC50 values for inhibition of Agam\Orco are presented as mean ± SEM (n = 3–8). Vapor pressures and boiling points were estimated as described in Methods.