Table 2.

Table of parameters.

Parameter	Value	Source
[G]	5 mM	*
λ	0.0775 mM−1	+
$V_{{\max }_{[\mathrm{g}]}}$	1.2 mM · min−1	38
$K_{m_{[\mathrm{g}]}}$	19 mM	38
δ	65 × 10−6 mM	*
$V_{{\max }_{[\mathrm{G}6\mathrm{P}]}}$	0.1845 mM · min−1	39
$K_{m_{[\mathrm{G}6\mathrm{P}]}}$	0.09 mM	38,*
$V_{{\max }_{[\mathrm{F}16\mathrm{BP}]}}$	1.365 mM · min−1	40
$K_{m_{[\mathrm{F}16\mathrm{BP}]}}$	3.5 mM	40
[PEP]eq	6.375 × 10−4 mM	*
$V_{{\max }_{[\mathrm{G}3\mathrm{P}]}}$	0.15 mM · min−1	*
$K_{m_{[\mathrm{G}3\mathrm{P}]}}$	0.143 mM	*
q	0.18	+
$V_{{\max }_{[\mathrm{NADPH}]}}$	0.228 mM · min−1	41
$K_{m_{[\mathrm{NADPH}]}}$	0.45 mM	41
$\tau$	1.5 × 103 min−1	+
$V_{{\max }_{[\mathrm{PYR}]}}$	0.3915 mM · min−1	39
$K_{m_{[\mathrm{PYR}]}}$	1.7 mM	39
$V_{\max {}_{[\mathrm{LACT}]}}$	0.14 mM · min−1	+
$K_{m_{[\mathrm{LACT}]}}$	0.125 mM	42
$\mathrm{\Psi }$	8 min−1	+
$\eta$	2 × 10−2	+
$\rho$	0.001	*
$\omega$	2 mM−1	+
r	0 mM · min−1	+
δ L	0.01 min−1	+
α	1 min−1	+
μ c	3.5 × 10−3 min−1	12
μ [ROS]	6.94 × 10−5 mM−1 · min−1	+
a n	6.94 × 10−8 min−1	12
μ n	6.25 × 10−3 min−1	12
$\mathrm{\Gamma }$	2.22 × 10−3 min−1	12
$\kappa$	3.47 × 10−11 min−1	12
β n	5.56 × 10−10 min−1	12
γ	6.94 × 10−11 min−1	12
$ϵ$	3.33 × 10−2 mM−1	+
p	1 × 10−15 mM · min−1	+
[g]0	3 mM	43
[G6P]0	0.45 mM	+
[F16BP]0	0.06 mM	+
[G3P]0	2.5 × 10−6 mM	+
[NADPH]0	1.2 × 10−4 mM	+
[PYR]0	7.5 × 10−4 mM	+
[LACT]0	1 × 10−4 mM	+
[ROS]0	0 mM	+
C 0	0.18 × 106	7
$R_{n_0}$	3.6 × 106	7
T 0	8.4 × 104	12

These are parameters when all processes in the retina are functioning properly. The parameters with a subscript zero represent the initial values for the biochemical concentrations and cell population level variables.

⁺These values were estimated for simulation analysis.

*The parameters were taken from a model of cone-enriched culture system that was used originally to identify RdCVF by high content screening⁶; see Supplemental Material A.2.