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. 2018 Mar 13;6(1):35–42. doi: 10.1016/j.gendis.2018.03.003

Figure 3.

Figure 3

Expression of VEGF in cells transfected with c.380G>C mutation, wild-type and empty vector. (A) Under hypoxic conditions, increased expression levels of VEGF mRNA in c.380G>C mutation were observed compared with wild-type. (B) No significant difference of VEGF mRNA expression was observed between c.380G>C mutation and wild-type during normoxia. (C) Under hypoxic conditions, increased expression levels of VEGF protein in c.380G>C mutation were observed compared with wild-type. (D) Under normoxic conditions, expression of VEGF protein in c.380G>C mutation is lower than that in wild-type. MT: c.380G>C mutation; WT: wild-type; vector: empty vector with no PHD2 expression; control: untreated group.