Fig. 7.

Clusters extracted for neuropsychology-connectivity correlation analyses included (A) ventral striatal (green) and medial prefrontal (yellow) clusters whose connectivity to the SN seed was significantly increased for PCA relative to HCs; a bilateral angular gyrus cluster (red) whose connectivity to the DMN seed was significantly increased for PCA relative to HCs; and a parietooccipital cluster (blue) whose connectivity to the visuospatial network seed was significantly decreased for PCA relative to HCs. Clusters of interest are largely in-network for SN (first two columns), DMN (third column), and visuospatial network (fourth column). Transparent networks are shown overlaid on clusters of interest (B). We derive these networks using one-sample t-tests showing voxels correlating strongly with the R frontoinsula (SN), R posterior cingulate (DMN), and PCA peak atrophy (visuospatial network) seeds in a non-overlapping group of HCs (Supplemental Table 1) from that used for comparison with the PCA group (C).