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. 2019 Mar 5;13:26. doi: 10.3389/fnins.2019.00026

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Copyright © 2019 Teng, Fan, Peng, He, Chen, Duan, Yang, Lin, Lin, Li and Shao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SIRT1 inhibitor sirtinol abolished the beneficial effect of carnosic acid on apoptosis. (A) Quantitative analyses of neurological scores. The bars represent the mean ± SD. n = 18. (B) Quantitative analyses of ROS. The histograms represent the median with interquartile range, n = 6. (C–E) Western blot assay and quantitative analyses of SIRT1 (D), p66shc (E) in PC12 cells after treatment with CA alone or together with sirtinol. ^∗P < 0.05 vs. Vehicle, ^#P < 0.05 vs. CA. (F–L) Western blot assay (F) and quantitative analyses of SIRT1 (G), p66shc (H), MnSOD (I), Bcl-2 (J), Bax (K), cleaved caspase-3 (L) expressions in ipsilateral cortex. The densities of the protein bands were analyzed in relation to β-actin and normalized to the sham group. The bars represent the mean ± SD. n = 6. ^∗P < 0.05 vs. SAH, ^#P < 0.05 vs. SAH + CA.