Table 2.
Putative epitopes of Kgp obtained from the peptide prediction analysis of the protein sequence (Brazil, 2018)
| Protein | HLA allele/haplotype | Peptide | Peptide sequence (15-mer) | Start | End |
|---|---|---|---|---|---|
| Kgp (1723 aa) |
DQA1*05:01/DQB1*03:01 | kgp1 | ESFGLGGIGVLTPDN | 1028 | 1042 |
| DQA1*05:01/DQB1*03:01 | kgp2 | LSPLRASNVAISYSS | 1467 | 1481 | |
| DQA1*05:01/DQB1*02:01 | kgp3 | TDMFYIDLDEVEIKA | 1137 | 1151 | |
| DQA1*05:01/DQB1*02:01 | kgp4 | GTAAADFEVIFEETM | 1533 | 1547 | |
| DQA1*01:02/DQB1*06:02 | kgp5 | MLGTMRGVRIAALTI | 160 | 174 | |
| DQA1*01:02/DQB1*06:02 | kgp6 | NVAISYSSLLQGQEY | 1474 | 1488 | |
| DRB3*01:01 | kgp9 | SDLNYILLDDIQFTM | 1317 | 1331 | |
| DRB3*01:01 | kgp10 | VLGIMIDDVVITGEG | 1579 | 1593 | |
| DRB1*13:02 | kgp11 | ANDVRANEAKVVLAA | 733 | 747 | |
| DRB1*13:02 | kgp12 | NYDVVITRSNYLPVI | 661 | 675 | |
| DRB1*15:01 | kgp13 | NYDVVITRSNYLPVI | 661 | 675 | |
| DRB1*15:01 | kgp14 | MRKLLLLIAASLLGV | 1 | 15 | |
| DRB1*07:01 | kgp15 | YVAFRHFQSTDMFYI | 1128 | 1142 | |
| DRB1*07:01 | kgp16 | PATGPLFTGTASSNL | 773 | 787 | |
| DRB5*01:01 | kgp17 | RMLVVAGAKFKEALK | 243 | 257 | |
| DRB5*01:01 | kgp18 | VPFVYNAAAYARKGF | 136 | 150 | |
| DRB4*01:01 | kgp19 | SDLNYILLDDIQFTM | 1317 | 1331 | |
| DRB4*01:01 | kgp20 | NYLPVIKQIQAGEPS | 670 | 684 |
Start and end correspond to the positions in the Kgp sequence. For Kgp 9/19 and Kgp 12/13, only one sequence was considered