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. 2019 Mar 5;13:23. doi: 10.3389/fnbeh.2019.00023

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Copyright © 2019 Borsoi, Manduca, Bara, Lassalle, Pelissier-Alicot and Manzoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sex-specific alteration of play behavior in pubescent rats 24 h after a single in vivo cannabinoid exposure. Twenty-four hours following a single exposure to WIN55,212-2 (WIN, 2 mg/kg, s.c.), pouncing was normal in male pubescent rats (A) in contrast to female littermates (B) whom displayed a marked reduction in the number of pouncing compared to Sham animals. Twenty-four hours following WIN exposure, pinning was similar to that of Sham animals in males (C) but was largely reduced in female littermates (D). WIN-exposed rats of both sexes (E, Male; F, Female) spent similar time sniffing the congener compared to their respective Sham groups. Data represent mean ± SEM. Scatter dot plot represents a pair of animals. *p < 0.05, Mann-Whitney U-test. ♂ Males (Sham n = 11 pairs; WIN n = 9 pairs); ♀ Females (Sham n = 10 pairs; WIN n = 9 pairs).