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. 2019 Mar 5;13:23. doi: 10.3389/fnbeh.2019.00023

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Copyright © 2019 Borsoi, Manduca, Bara, Lassalle, Pelissier-Alicot and Manzoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intact memory discrimination in the novel object recognition test 24 h after single in vivo cannabinoid exposure in both pubescent and adult male and female rats. Animals were tested 24 h after a single exposure to WIN55,212-2 (WIN, 2 mg/kg, s.c.). Recognition index between the novel and familiar objects were similar in male (A) and female (B) WIN-treated pubescent rats compared to their respective Sham groups. Similarly, no differences were observed in recognition index in male (C) and female (D) adult rats treated with WIN. Data represent mean ± SEM. Scatter dot plot represents one animal. Mann-Whitney U-test. ♂ Males (Pubescents: Sham n = 10 and WIN n = 9; Adults: Sham n = 8 and WIN n = 9); ♀ Females (Pubescents: Sham n = 9 and WIN n = 13; Adults: Sham = 5 and WIN = 7).