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. 2019 Mar 5;13:92. doi: 10.3389/fnins.2019.00092

FIGURE 3.

FIGURE 3

Effects of cold challenge or CL 316,243 treatment for 1 week or 4 weeks on the TBR-2 and Ki-67 positive cells in the dentate gyrus. Note that the TBR-2 and Ki-67 positive cells are abundant in the Cold1W and Cold4W groups when compared with that in the CON Cold1W and CON Cold 4W groups, respectively (A,C,E,G). However, the CON CL1W, CL1W, CON CL4W, and CL4W groups show similar populations of TBR-2 and Ki-67 positive cells in the dentate gyrus (A,C,E,G). GCL, granule cell layer; MoL, molecular layer; PoL, polymorphic layer. Quantitative analysis of TBR-2 and Ki-67 positive cells per section in the CON Cold1W, Cold1W, CON Cold4W, Cold4W, CON CL1W, CL1W, CON CL4W, and CL4W groups (B,D,F,H) (n = 5 per group); ∗ indicates a significant difference when compared with the CON group (p < 0.05); and ∗∗ indicates a significant difference when compared with the CON group (p < 0.01). Data are shown as mean + SEM. Black scale bar = 100 μm and green scale bar = 25 μm.