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. 2019 Mar 5;10:193. doi: 10.3389/fphar.2019.00193

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Copyright © 2019 Marton, González, Rodríguez-Bottero, Miquel, Martínez-Palma, Pazos, Prieto, Rodríguez, Sames, Seoane, Scorza, Cassina and Carrera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ibogaine administration on BDNF expression in specific brain areas. Quantitative analysis of BDNF transcript levels in the indicated brain areas after 3 h (upper panels) or 24 h (lower panels) of vehicle (0), 20 or 40 mg/kg ibogaine administration. For 3 h after treatment PFC, N = 16, P < 0.0001, F_2,13 = 9.80, η² = 0.61; For 24 h after treatment PFC, N = 16, P < 0.0001, F_2,13 = 25.26, η² = 0.80; For 24 h after treatment NAcc, N = 15, P < 0.0001, F_2,12 = 46.62, η² = 0.89; For 24 h after treatment VTA, N = 14, P < 0.0001, F_2,11 = 46.46, η² = 0.88; For 24 h after treatment SN, N = 16, P < 0.0001, F_2,13 = 45.50, η² = 0.88; ^∗ P < 0.05, ^∗∗ P < 0.01 and ^∗∗∗P < 0.001 between indicated groups.