Table 1.
Genetic pleiotropy and enrichment of functional deleteriousness among genetic loci associated with birthweight and adult cardiometabolic disease traits.
| Cardiometabolic disease traits (CMD) | Genetic pleiotropy | Functional annotation enrichment | ||
|---|---|---|---|---|
| Enrichment fold (s.e.) | P-value | q11/q00 (s.e.) | P-value | |
| Coronary artery disease | 8.61 (0.09) | <10−300 | 1.25 (0.06) | 6.87 × 10−22 |
| Myocardial infarction | 8.13 (0.11) | <10−300 | 1.14 (0.08) | 1.01 × 10−18 |
| Type 2 diabetes | 14.14 (0.28) | <10−300 | 1.45 (0.09) | 1.73 × 10−21 |
| Fasting glucose | 8.22 (0.97) | 4.58 × 10−24 | 0.47 (0.99) | 0.44 |
| Fasting insulin | 3.69 (0.16) | 3.52 × 10−77 | 1.15 (0.21) | 1.46 × 10−21 |
| Hemoglobin A1c | 5.37 (0.16) | 2.35 × 10−233 | 1.29 (0.15) | 1.63 × 10−22 |
| Insulin secretion | 7.39 (0.60) | 1.91 × 10−110 | 1.29 (0.29) | 1.66 × 10−21 |
| Insulin sensitivity | 6.89 (0.38) | 8.90 × 10−110 | 1.13 (0.26) | 9.00 × 10−23 |
| HDL cholesterol | 6.39 (0.11) | <10−300 | 1.66 (0.09) | 1.31 × 10−28 |
| LDL cholesterol | 4.92 (0.11) | <10−300 | 1.72 (0.11) | 5.61 × 10−33 |
| Total cholesterol | 4.67 (0.09) | <10−300 | 1.66 (0.09) | 8.39 × 10−36 |
| Triglycerides | 4.78 (0.11) | <10−300 | 1.48 (0.13) | 2.78 × 10−27 |
| Waist circumference | 5.66 (0.09) | <10−300 | 1.45 (0.08) | 2.7 × 10−40 |
| Body mass index | 3.94 (0.05) | <10−300 | 1.42 (0.06) | 3.72 × 10−54 |
| Waist-to-hip ratio | 7.05 (0.12) | <10−300 | 1.86 (0.05) | 3.66 × 10−40 |
q11/q00 is the ratio of the probability of jointly associated SNPs being functionally annotated to the probability of a null SNP (not associated with neither trait) being functionally annotated.