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. 2019 Mar 11;9:4159. doi: 10.1038/s41598-019-40128-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Features of neural network activity for co-cultures grown in the presence and absence of an ECM coating. Bar graph summarizes each electrophysiology feature across a period of ~30 DIV for each experimental condition: PDL (white), MaxGel (red), and bECM (blue). Features of neural activity include: overall firing rate (a), interspike interval (b), burst per minute (c), percentage of spikes inside of bursts (d), burst duration (e) and interburst interval (f). Individual data points are represented as open circles, and summary data bars are presented as mean ± SEM for the number of devices in PDL (n = 5), MaxGel (n = 4) and bECM (n = 6). Data were analyzed using repeated measures two-way ANOVA with Tukey’s post hoc test. Statistical significances are at a level of *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.