Table 1.

Areas of significant brain activation for the analysis of state fatigue during the N-Back task. ‘BA’ denotes Brodmann Area; ‘X’, ‘Y’, and ‘Z’ denote the location of the voxel in the cluster with the highest activation; ‘Voxels’ denotes the number of voxels in each cluster; ‘F stat.’ denotes the F-statistic associated with the voxel of highest activation.

VAS-F (state) Fatigue and N-Back related activation
	BA	X	Y	Z	Voxels	F stat.
VAS-F Main effect
Postcentral Gyrus	43	−62	−6	14	1709	16.58
Middle Temporal Gyrus	20	46	−2	−26	218	16.81
Superior Temporal Gyrus	40	−60	−36	24	140	11.65
Superior Parietal Lobule	7	−22	−74	50	125	12.32
Putamen	–	22	−4	12	113	16.79
Group Main effect
Temporal Pole/Inferior Frontal Gyrus	22/44	−60	4	2	153	17.17
Superior Temporal Gyrus	13	−38	−18	−8	255	13.92
Middle Temporal Gyrus	39	−52	−72	24	1139	23.34
Inferior Parietal Lobule	40	42	−52	40	113	11.48
Inferior Parietal Lobule	40	−52	−34	48	110	10.65
Cuneus	18	−2	−80	28	435	15.72
Cerebellar Vermis	–	0	−48	−2	386	20.66
Group × VAS-F Interaction
Inferior Frontal Gyrus	13	30	14	24	208	10.40
Inferior Frontal Gyrus	44	−48	18	12	107	10.90
Caudate Nucleus	–	−14	14	22	161	9.71
Middle Temporal Gyrus	20	46	−2	−26	106	12.18
Task × VAS-F Interaction
Caudate Tail	–	28	−38	26	123	18.96
Hippocampus	22	40	−24	−8	314	15.69
Hippocampus	–	36	−42	12	104	15.00
Hippocampus	28	−10	−12	−14	127	26.50
Thalamus	–	16	−28	−2	128	21.14
Group × Task Interaction
Middle Orbital Gyrus	11	−4	40	−18	938	13.03
Middle Frontal Gyrus	10	40	58	10	131	10.29
Middle Frontal Gyrus	6	−44	6	50	180	15.42
Inferior Frontal Gyrus	47	−42	24	−6	367	13.07
Caudate Nucleus	–	24	26	−2	368	19.21
Calcarine Gyrus	17	−6	−68	10	239	12.10
Thalamus	–	8	−26	−8	224	10.43
Group × Task × VAS-F Interaction
Caudate Tail	–	28	−38	26	267	20.76
Hippocampus	22	38	−22	−10	966	26.61
Hippocampus	–	−34	−32	−4	117	11.62