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. 2019 Mar 5;13:126. doi: 10.3389/fnins.2019.00126

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Copyright © 2019 Prayag, Jost, Avouac, Dumortier and Gronfier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Duration response curves of non-visual functions in humans. The response magnitudes were plotted against duration of light exposure and fitted with a 4-parameter logistic model. (A) Response change (% change from baseline dim light) during light exposure differed between functions. The maximal responses vary between ∼6% (EEG delta activity) and ∼60% for the pupillary light reflex (PLR; tonic pupil response). (B) Relative responses reveal that sensitivity differs between non-visual functions. EC50s (half-maximum values) range between ∼48 s (tonic pupil response) and ∼12 min (EEG gamma activity). Parameter estimates and R² values are given in Supplementary Table 5.