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. 2019 Mar 11;9:4026. doi: 10.1038/s41598-019-40436-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of 4MU treatment in HBV-TG mice. (A) Macroscopic appearance of liver after 12 weeks treatment of 25 and 50 mg/kg/day 4MU (scale bar = 1 cm). (B) HA staining of the liver before and after treatment. Magnification: 200X (scale bar = 300 µm). (C) Relative mRNA expressions of hyaluronan synthases Has2 and Has3, and hyaluronidases Hyal1 and Hyal2. (D) Relative mRNA expressions of fibrosis and ECM genes Fsp1 and Acta2. Each mRNA expression of target genes was normalized to reference genes Gapdh and Actb. Statistical analysis: *p < 0.05, **p < 0.01 compared to WT 0 mg/kg/day, ^#p < 0.05, ^##p < 0.01 compared to TG 0 mg/kg/day. WT = wild type mice, HBV-TG = HBV-transgenic mice.