Fig. 1.

PHPT mice exhibits reduced body weight, decreased fat content, and improved glucose torerance and insulin sensitivity.

(a) The palsma PTH levels of mice 4 months after virus injection. N = 10 and 12 in GFP and PHPT group, respectively. (b) The serum calcium 4 months after injection. N = 8 in each group. (c) The bone mineral density of distal femur 21 days after virus injection. N = 8 in each group. (d) The body weight of the mice groups followed by virus injection. N = 10 and 12 in GFP and PHPT group, respectively. (e) The changing value of body weight followed by virus injection. N = 10 and 12 in GFP and PHPT group, respectively. For the left panel, independent t-test was performed to make comparisons between GFP and PHPT group. For the right panel, paired t-test was performed to make comparisons between the body weight on 110d and baseline. (f-g) The absolute and relative fat mass and lean mass measured 3.5 months after virus injection. N = 10 and 11 in GFP and PHPT group, respectively. (h) The absolute weight of adipose tissue in mice 4 months after virus injection. N = 10 and 12 in GFP and PHPT group, respectively. (i) The relative adipose tissue weight adjusted by body weight 4 months after virus injection. N = 10 and 12 in GFP and PHPT group, respectively. (j) The intraperitoneal glucose tolerance test performed 3 months after virus injection. N = 10 and 12 in GFP and PHPT group, respectively. (k) The insulin tolerance test performed 3.5 months after virus injection. N = 10 and 12 in GFP and PHPT group, respectively. Data are shown as Means ± SEMs. *P < .05, **P < .01, ***P < .001 vs GFP group.