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SUMOylation regulates Liver Kinase B1 (LKB1) nucleocytoplasmic shuttling and its oncogenic potential in liver cancer. LKB1 acetylation at Lys48 and posterior SUMOylation at Lys178 by SUMO-2 account for the nuclear retention of LKB1 in liver cancer by hampering the binding of LKB1 to STRADα.
