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. 2019 Mar 11;9:4112. doi: 10.1038/s41598-019-38580-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cleavage of HSP90 and degradation of PKD2 following cold plasma treatment is associated with cancer cell death. Physical plasma treatment- generated ROS is followed by HSP90 cleavage and subsequent destabilization and degradation of PKD2. While PKD2 degradation plays an important role in cancer cell death, additional essential molecules such as STK33, also contribute to the apoptotic event. Furthermore, pre-treatment of cancer cells with subliminal doses of HSP90 inhibitor followed by cold plasma treatment boosts cell death in human cancer.