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. 2019 Mar 11;10(3):239. doi: 10.1038/s41419-019-1481-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative data extracted from TCGA datasets showing the relative expression of SOX12 mRNA in multiple cancer tissues compared with normal tissues. The box-and-whisker plots show the medians (horizontal lines), interquartile ranges (boxes), and minimum and maximum values (whiskers) of the data. COAD colon adenocarcinoma, KIRC kidney renal clear cell carcinoma, LIHC liver hepatocellular carcinoma, UCEC uterine corpus endometrial carcinoma; **P < 0.01 and *P < 0.05. b Kaplan–Meier analysis showing the correlation between SOX12 mRNA expression and OS for the patients included in the TCGA datasets. c RT-PCR analysis showing the pattern of SOX12 expression in human CRC tissues compared with adjacent nontumor tissues, metastatic CRC compared with nonmetastatic CRC, recurrent CRC compared with nonrecurrent CRC, and metastatic CRC compared with primary CRC. d Western blotting analyses performed using human CRC tissues and adjacent nontumor tissues. e IHC staining for SOX12 in human CRC tissues. The scale bars represent 200 µm (upper panel) and 50 µm (lower panel). f Kaplan–Meier analysis revealed a positive correlation between SOX12 expression and tumor recurrence, and a negative correlation with OS. *P < 0.05, **P < 0.01 compared with the control. The data are presented as the mean ± SD