Fig. 2.

Cell population and subset alterations over time. (A) Changes in naïve (purple) and memory (green) B cells within the first 6 months of belimumab treatment visualised by t-SNE clustering of CD20⁺ B cells. (B–K) Relative cell count alterations in predefined cell subsets on each follow-up occasion compared to baseline values, with lines representing medians and error bars representing quartiles. Spearman's rank correlation coefficients (ρ) for correlations of cell populations with time from baseline and the corresponding P-values are shown in the respective graphs. See Fig. 1A for the number of datapoints. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)