Table 3.

Summary of percentage change from baseline in mean FLU-PRO total symptom scores by treatment group and visit in the mITT (confirmed influenza) population.

Total symptom score parameter, by visit	VIS410 Total (N = 90)	VIS410 4000 mg (N = 46)	VIS410 2000 mg (N = 44)	Placebo (N = 48)
Baseline Mean (SD)	1.92 (0.62)	1.93 (0.65)	1.91 (0.59)	1.95 (0.70)
Percent Change from Baseline to Day 2, mean (SD)	−28.01 (28.18)	−26.12 (27.00)	−29.98 (29.55)	−19.53 (26.51)
Difference vs Placebo (p-value)	0.158	0.429	0.101
Percent Change from Baseline to Day 3, mean (SD)	−43.89 (29.53)	−38.65 (28.78)	−49.37 (29.62)	−33.63 (23.60)
Difference vs Placebo (p-value)	0.025	0.436	0.002
Percent Change from Baseline to Day 4, mean (SD)	−56.21 (28.67)	−53.46 (26.16)	−59.08 (31.12)	−44.55 (28.20)
Difference vs Placebo (p-value)	0.007	0.097	0.003
Percent Change from Baseline to Day 5, mean (SD)	−62.69 (27.66)	−60.85 (25.52)	−64.61 (29.91)	−56.75 (24.31)
Difference vs Placebo (p-value)	0.061	0.290	0.030
Percent Change from Baseline to Day 6, mean (SD)	−68.08 (27.61)	−69.31 (20.90)	−66.80 (33.42)	−64.01 (23.35)
Difference vs Placebo (p-value)	0.107	0.256	0.100
Percent Change from Baseline to Day 7, mean (SD)	−72.43 (25.71)	−74.03 (19.31)	−70.76 (31.18)	−71.51 (20.61)
Difference vs Placebo (p-value)	0.237	0.406	0.228
Percent Change from Baseline to Day 8, mean (SD)	−77.02 (23.13)	−77.98 (20.76)	−76.03 (25.53)	−76.16 (21.01)
Difference vs Placebo (p-value)	0.497	0.569	0.552
Percent Change from Baseline to Day 9, mean (SD)	−79.27 (22.91)	−80.05 (19.78)	−78.48 (25.95)	−79.52 (19.84)
Difference vs Placebo (p-value)	0.704	0.958	0.547
Percent Change from Baseline to Day 10, mean (SD)	−81.85 (20.14)	−82.30 (20.07)	−81.38 (20.43)	−84.35 (17.52)
Difference vs Placebo (p-value)	0.585	0.504	0.793