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. 2019 Mar 5;10:168. doi: 10.3389/fphys.2019.00168

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Copyright © 2019 Ambrosi, Sadananda, Han and Entcheva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed mechanisms of infectivity for AAV1, 6, and 9. (A) Cell surface N-linked sialic acid has been proposed as the primary receptor for AAV1 and 6 to infect and transduce cells. The removal of sialic acid by neuraminidase (targeting the portion of the glycoprotein indicated by the arrow) is expected to block the AAV1,6-mediated transduction of cells. (B) AAV9-mediated cell infection/transduction has been attributed to two receptors: terminal galactose on cell surface glycoproteins (left panel) and the 37/67 kDa laminin receptor (LamR) (right panel).