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. 2019 Mar 11;9:4032. doi: 10.1038/s41598-019-39483-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expansion of B cell populations in IL-17RA KO/lpr mice. (A) Total numbers of splenic B cells (CB19+) in wildtype and lpr mice. Bars depict wild type B6 (grey stripe), IL-17RA KO (open stripe), B6/lpr (black), and IL-17RA.KO/lpr (open) mice at 10, 20, and 30 weeks of age. [B] Total numbers of splenic follicular B cells (CD19+ B220+ CD21− CD23+),marginal zone B cells (CD19+ B220+ CD21+ CD23−), transitional B cells (CD19+ B220+ CD21− CD23−), and germinal centre B cells (CD19+ B220+ PNA+ CD95+) in B6/lpr and IL-17RA KO/lpr mice at different ages. (C) Total numbers of IgM, IgG1 and IgG2 producing CD138+ plasma cells at different ages. Mean and SEM are shown for n = 9–21 animals per group; *p < 0.05; **p < 0.01; ***p < 0.001.